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Mesalazine dose medscape.com/drugnews/view/165893/SALT-Liver-Dose-Cut-Flu-Rate A study published in the Journal of American Medical Association in 1999 found a significant association between the use of non-steroidal anti-inflammatory drug (NSAIDs)/pain relievers and the incidence of severe hyponatremia (low vitamin B-12 levels resulting from impaired renal function).[1] Possible risk of NSAID use for hyponatremia. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5287292/ References 1. Ebersole J, et al, 1999. Association of Nonsteroidal Anti-inflammatory Drug Use and Symptomatic Hypertension among Elderly Americans: A Nationwide Follow-Up Study. JAMA, 282:2058 – 2062 2. Niell M, et al, 1998. Serum- and plasma-high-sodium levels as predictors of outcome in the hyponatremia-induced nephropathy. Blood, 89:1219 – 1229 3. Hoehne Generic version of valium K, et al, 1997. A comparison of non-steroidal anti-inflammatory drugs and potassium-sparing diuresis. Ann Intern Med 108:1517 – 1519 4,5. Volek JR, 1997. Proton pump inhibitors. In: Clements A, Williams R, eds. Drug Interactions: Clinical Pharmacology and Therapeutic Equivalence. CRC Press, Boca Raton, FL, pp 446–482. 6. Stolzberg B, Kosteljanetz A, 1998. The risk for hyponatraemia after use of aspirin or nonsteroidal anti-inflammatory drugs. Acta Derm Venereol 71:19–23 7. Diamant H, et al, 1990. Inhaled corticosteroids as an aid to the pharmacological treatment of hypercholesterolemia (lipoprotein(a)*). Lancet i:14–18 8. Rössner S, 1994. The risk for hyponatremia during anticonvulsant therapy. Eur Neurol 24:542–547 Back to top [top] [back to top] How to Recognize a Low Serum Sodium Level — What Is the Best Way to Manage It? If you experience hyponatraemia symptoms or signs, there are a number of measures you can take. One way of recognizing hyponatraemia symptoms is by feeling lightheaded, your head may feel heavy or like you may pass out while walking, getting up suddenly (even for just a couple steps) may make you feel ill or faint, your eyes may look bloodshot or you feel may be "sunken in your seat." While at rest and feeling well, you can also have trouble with balance and/or thinking. You should be able to perform basic daily activities. You should check your urine in the first 24 hours from an acute episode of hyponatraemia. It is important to remember that the normal range for sodium levels most adults is between 1.6 and 2.4mEq/L, however, a number of studies have shown a range between 1.9 to 1.9mEq/L.[1–4] Another warning sign is the following: dizziness and disorientation, confusion, loss of balance[5–7]. You may also experience nausea, nausea and vomiting due to lack of salt in your blood and fluid accumulation in your stomach and intestines.[6–7] Your blood will also show a decrease in potassium levels if it contains < 5.9mEq/L of potassium.[1–4] If your potassium level is too low ( < 5.9mEq/L), you must take a potassium intake of ≥ 15g per day. Some research suggests that if we do not have severe hyponatremia, you can consume 6 to 8g of potassium per day for 10-14 days (if severe hyponatraemia and acidosis occurs). However, a very small number of patients in the research studies reported no improvement in their symptoms when potassium treatment was started soon after the onset of hyponatraemia, while it took up to 20mg of potassium per day for 7 days or up to 60mg of potassium per day for 28 days to prevent seizures.[6–7], see: How Improve Symptoms of Low Sodium Level If you feel may be having an episode of subacute hyponatraemia (when there is some degree of symptom improvement within the first few hours of episode but there will be no longer improvement, even if the person has)