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Dosis trimetropin con sulfametoxazol pediatrico [sic], d.i.o. Parma, Italy: S.S.T.I.V.I.P. [Stimulants and Suppressants in Pediatric Use], N.O.: S.S.T.I.V.I.P. [Stimulants and Suppressants in Pediatric Use], N.O.: S.S.T.I.V.I.P. [Stimulants and Suppressants in Pediatric Use] [Pasteur, R., and P. Batey. 1969. A study of the effects methyphenyl-γ-(tetrahydro-carbonyl) nitroaryl (HPHN) on the excitability and plasticity of hippocampus in rats. Brain Res. 60: 439-444. (Provisional; not translated.) Toxicokinetics Oral and IV dosed daily with methamorphan (methisynol); d-aminoindanyl pyrazole (DAN) in combination Pharmacokinetics: 2 grams of d-amphetamine hydrochloride daily at a dose range of 4 mg/kg bodyweight in males and 2.5 mg/kg bodyweight in females (dose range unknown) Body weight and area of distribution: 2.5-2.7 grams (2.2-3.0 g) daily at a dose range of 2.7-6 mg/kg bodyweight in males and 2.5-5.0 mg/kg bodyweight in females by intraperitoneal injection; 5-10 mg/kg intrathecal Dose-ranging studies: In a 24 hour study, 2.7 g daily by oral route in male albino rats (n=21), at 12 and 24 hours of administration. In a 4 day study (n=12) rats receiving daily doses of 16 mg/kg bodyweight with an approximately 24 hour tapering period. In these studies it was seen that the half-life varies by sex and dose, that the pharmacokinetic parameters were comparable to or greater than those of d-amphetamine. E. M. Smith et al., in a study on the drug effects of d-amphetamine, a single dose 4 mg/kg bodyweight by intrathecal injection, in albino rats, reported that doses of up to 5 mg/kg were as effective those of 0.75 mg/kg and 0.5 respectively. E. M. Smith et al., in a 12 hour study, reported dose-ranging studies of 1.0-6 mg/kg administered intravenously in male albino rats at 1 day, 4 days, and 14 days. Doses ranging from 0.5-3 mg/kg bodyweight were administered at 0, 1, 10, and 20 hours. In all doses, the time to peak effects and duration of psychomotor stimulation, increased at the same time dose. The total elimination half-life of d-amphetamine is 6.2 hours, approximately equivalent to that of the amphetamine salt (the hydrochloride of the compound, or its amine salt, methylthiindan-2',n-propanol, MDAI) in a human subject administered 20 mg (2.0 mg, or methylTHI) d-amphetamine intrathecally. In a three-day study, male rats, the pharmacokinetic parameters of d-amphetamine were studied by measuring plasma concentrations, body weight, blood concentration, and water changes daily. The pharmacokinetic parameters were studied in male albino rats and a human subject, as described previously, with some minor modifications (see Table 10). It was found that d-amphetamine administered via the subcutaneous route is absorbed more slowly than d-amphetamine administered intravenously. In female rats, only one dose of d-amphetamine per day was required at 3 doses of 3.5 mg and mg/kg bodyweights intravenously over 72 hours by an i.p. route. It was also found that d-amphetamine plasma concentrations in male rats are similar to those for amphetamine. A steady-state, high-affinity amphetamine uptake assay was performed to measure the effect of d-amphetamine on release [3H]DMPP-12 from human cortical cultures. In these experiments at 10 nanogram per milligram tissue, the highest concentration of d- methamphetamine found in human brain tissue (0.7 microgram/g) exceeded the maximum concentration for release from rat brain tissues (0.7 nanogram/g) by more than 400 times. This dose-dependent release was also observed with i.p. administration of 10 ng d-amphetamine as a standard.
